Registration & Morning Coffee
Chairperson’s Opening Remarks
Understanding the Ecology of the Skin Microbiome for Better or for Worse; in Homeostasis or Dysbiosis
Whilst directed discovery has focused on understanding ‘who’s there’ in the skin microbiome, the majority of host-microbe and microbe microbe interactions remain unclear. The purpose of this theme is to showcase new research on how our knowledge has progressed in terms of skin microbiome composition and what we know in terms of microbial interdependence, synergy, competition and how this can be applied to microbial product development.
Investigating a Skin Probiotic, Prebiotic and Electro-biotic for Microbiome Banking
• Defining how to create specific prebiotics for probiotic bacteria that stimulate the bacteria to produce electrons
• Understanding the beneficial impact that this type of stimulation has on the skin microbiome
UC San Diego
From Swab to Data – Considerations for Designing Skin Microbiome Studies
• Understanding how the different steps in designing skin microbiome studies, from sampling to the generation of sequencing data, can impact the quality of your data and resulting interpretation of the ecology and function of skin microbes
• Exploring how skin microbiome studies differ from those of other body sites, including the challenges of working with low-biomass samples
• Understanding that there are numerous important considerations for designing skin microbiome studies, including sampling techniques, which amplicon region to use for sequencing and key bioinformatic considerations of data generation
Speed Networking & Morning Refreshments
Sequencing & Beyond - The Next Frontier for Truly Understanding the Skin Microbiome
There remains a gap in fully characterizing the skin microbiome at strain level and translating this knowledge to understand how, why and when microbial products perform at a fundamental genomic level. The purpose of this session is to present new approaches to genome sequencing, bioinformatics, metatranscriptomics and metabolomics and understand how sequencing platforms are improving our understanding of the skin microbiome.
Highlighting How to Combine Metabolomics & Sequencing – Using a Longitudinal Study Example
• Revealing how to conduct skin cartography work
• Interpreting functional data to understand how genomics translate into proteins that shape the composition of the skin microbiome
• Using metabolomics approaches in a longitudinal study example – how to crunch through relevant data?
UC San Diego
Unlocking the Skin Microbiome: From R&D to Product
Study of the Human Skin Microbiome at the Strain-Level
• Outlining why strain-level analysis of the skin microbiome is essential in understanding health and disease and defining potential translational applications of this type of analysis
• Demonstrating sequence analysis data of the skin microbiome at the strain-level
• Understanding how transcriptional activities, metabolic activities, and host immune response are distinct among different strains of skin bacteria in health and acne
Lunch & Networking
Comprehensive, High-Confidence, & Non-Invasive Metabolomic Profiling of the Skin
• Generating novel insights into skin function and the skin microbiome through metabolomic and lipidomic analysis of stratum corneum tape strips
• Providing the highest-confidence identification and precise measurement of several hundred metabolites of mammalian, microbial, and xenobiotic origin in the skin through the Global Metabolomics Platform
• Highlighting the power to discover significant differences in skin biochemistry: case examples of sex, age, and skin condition
• Identifying metabolites as a critical mediator of host-microbe interaction in skin health and disease
Long Read Sequencing of the Skin Microbiome
• Loop long-read microbiome sequencing provides insight into skin microbiome diversity
• Single molecule counting enables absolute abundance of skin microbiomes instead of amplification biased measures of relative abundance
• Track specific strains and species from less than 1ng of DNA with Loop’s singlemolecule long-read microbiome sequencing technology
Exploring the Role of the Gut-Skin Axis in Skin Health
Emerging evidence has highlighted the role of the gut-skin-brain axis in skin health. This theme will demonstrate the latest research on establishing the immune-gut microbiome interactions that lead to skin microbial dysbiosis.
Using Advanced Omics Technologies & Machine Learning for Data-Driven Personalized Nutrition, Probiotics & Medicine
• Exploring how skin health is affected by the immune system, which is modulated by diet and gut microbiome
• Discussing how gut microbiome biochemical output, and not taxonomy, modulate human immune system and physiology
• Sharing Viome’s platform for making personalized diet recommendations that can be used to reduce skin conditions
Director of Translational Science
Afternoon Refreshments & Networking
The purpose of this theme is to address broader questions regarding microbial-based products for the skin in an informal setting to build a better understanding of their critical need and use. Questions to be discussed include:
15.30 How can we ensure that antiseptic treatments
retain reduction of symptoms (e.g. itching, cleansing and prevention of infection on skin lesions etc) but also retain barrier function and health of the skin microbiome?
15.30 How can translational learnings from both the therapeutic and cosmetic space be used to achieve personalized skin care?
15.30 How are personal care products, such as cleansers, being assessed for their impact on the skin microbiome?